Molecular Evolutionary Analysis of ABCB5: The Ancestral Gene Is a Full Transporter with Potentially Deleterious Single Nucleotide Polymorphisms

BACKGROUND: ABCB5 is a member of the ABC protein superfamily, which includes the transporters ABCB1, ABCC1 and ABCG2 responsible for causing drug resistance in cancer patients and also several other transporters that have been linked to human disease. The ABCB5 full transporter (ABCB5.ts) is express...

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Detalles Bibliográficos
Autores principales: Moitra, Karobi, Scally, Mark, McGee, Kate, Lancaster, Germaine, Gold, Bert, Dean, Michael
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029322/
https://www.ncbi.nlm.nih.gov/pubmed/21298007
http://dx.doi.org/10.1371/journal.pone.0016318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029322/
https://www.ncbi.nlm.nih.gov/pubmed/21298007
http://dx.doi.org/10.1371/journal.pone.0016318

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