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Determinants Outside the DevR C-Terminal Domain Are Essential for Cooperativity and Robust Activation of Dormancy Genes in Mycobacterium tuberculosis

BACKGROUND: DevR (also called as DosR) is a two-domain response regulator of the NarL subfamily that controls dormancy adaptation of Mycobacterium tuberculosis (M. tb). In response to inducing signals such as hypoxia and ascorbic acid, the N-terminal receiver domain of DevR (DevR(N)) is phosphorylat...

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Detalles Bibliográficos
Autores principales: Gautam, Uma Shankar, Chauhan, Santosh, Tyagi, Jaya Sivaswami
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029386/
https://www.ncbi.nlm.nih.gov/pubmed/21304599
http://dx.doi.org/10.1371/journal.pone.0016500