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Control of the specificity of T cell-mediated anti-idiotype immunity by natural regulatory T cells

The idiotypes of B cell lymphomas represent tumor-specific antigens. T cell responses induced by idiotype vaccination in vivo are directed predominantly against CDR peptides, whereas in vitro T cells also recognize framework-derived epitopes. To investigate the mechanisms regulating the specificity...

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Detalles Bibliográficos
Autores principales: Warncke, Max, Buchner, Maike, Thaller, Gudrun, Dodero, Anna, Bulashevska, Alla, Pfeifer, Dietmar, Timmer, Jens, Veelken, Hendrik
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029831/
https://www.ncbi.nlm.nih.gov/pubmed/20848095
http://dx.doi.org/10.1007/s00262-010-0918-x