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Improved Precursor Directed Biosynthesis in E. coli via Directed Evolution
Erythromycin and related macrolide antibiotics are widely used polyketide natural products. We have evolved an engineered biosynthetic pathway in Escherichia coli that yields erythromycin analogs from simple synthetic precursors. Multiple rounds of mutagenesis and screening led to the identification...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030684/ https://www.ncbi.nlm.nih.gov/pubmed/21081955 http://dx.doi.org/10.1038/ja.2010.129 |