Ablation of Akt2 Induces Autophagy through Cell Cycle Arrest, the Downregulation of p70S6K, and the Deregulation of Mitochondria in MDA-MB231 Cells

BACKGROUND: Akt/PKB is a promising anticancer therapeutic target, since abnormally elevated Akt activity is directly correlated to tumor development, progression, poor prognosis and resistance to cancer therapies. Currently, the unique role of each Akt isoform and their relevance to human breast can...

Descripción completa

Detalles Bibliográficos
Autores principales: Santi, Stacey A., Lee, Hoyun
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031501/
https://www.ncbi.nlm.nih.gov/pubmed/21297943
http://dx.doi.org/10.1371/journal.pone.0014614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031501/
https://www.ncbi.nlm.nih.gov/pubmed/21297943
http://dx.doi.org/10.1371/journal.pone.0014614

Ejemplares similares