Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease

Alzheimer's disease (AD), an incurable, progressive neurodegenerative disorder, is the most common form of dementia. Therapeutic options have been elusive due to the inability to deliver proteins across the blood-brain barrier (BBB). In order to improve the therapeutic potential for AD, we util...

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Detalles Bibliográficos
Autores principales: Spencer, Brian, Marr, Robert A., Gindi, Ryan, Potkar, Rewati, Michael, Sarah, Adame, Anthony, Rockenstein, Edward, Verma, Inder M., Masliah, Eliezer
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031588/
https://www.ncbi.nlm.nih.gov/pubmed/21304989
http://dx.doi.org/10.1371/journal.pone.0016575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031588/
https://www.ncbi.nlm.nih.gov/pubmed/21304989
http://dx.doi.org/10.1371/journal.pone.0016575

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