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Epistatic Interactions in Genetic Regulation of t-PA and PAI-1 Levels in a Ghanaian Population
The proteins, tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1), act in concert to balance thrombus formation and degradation, thereby modulating the development of arterial thrombosis and excessive bleeding. PAI-1 is upregulated by the renin-angiotensin system (RAS),...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031598/ https://www.ncbi.nlm.nih.gov/pubmed/21304999 http://dx.doi.org/10.1371/journal.pone.0016639 |