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Epistatic Interactions in Genetic Regulation of t-PA and PAI-1 Levels in a Ghanaian Population

The proteins, tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1), act in concert to balance thrombus formation and degradation, thereby modulating the development of arterial thrombosis and excessive bleeding. PAI-1 is upregulated by the renin-angiotensin system (RAS),...

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Detalles Bibliográficos
Autores principales:	Penrod, Nadia M., Poku, Kwabena A., Vaughn, Douglas E., Asselbergs, Folkert W., Brown, Nancy J., Moore, Jason H., Williams, Scott M.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031598/ https://www.ncbi.nlm.nih.gov/pubmed/21304999 http://dx.doi.org/10.1371/journal.pone.0016639

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