Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation

Genetic and biochemical abnormalities of α-synuclein are associated with the pathogenesis of Parkinson's disease. In the present study we investigated the in vivo interaction of mouse and human α-synuclein with the potent parkinsonian neurotoxin, MPTP. We find that while lack of mouse α-synucle...

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Detalles Bibliográficos
Autores principales: Thomas, Bobby, Mandir, Allen S., West, Neva, Liu, Ying, Andrabi, Shaida A., Stirling, Wanda, Dawson, Valina L., Dawson, Ted M., Lee, Michael K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031616/
https://www.ncbi.nlm.nih.gov/pubmed/21304957
http://dx.doi.org/10.1371/journal.pone.0016706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031616/
https://www.ncbi.nlm.nih.gov/pubmed/21304957
http://dx.doi.org/10.1371/journal.pone.0016706

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