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The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600)

BACKGROUND: In Italy, cervical cancer screening programmes actively invite women aged 25–64 years. Programmes are hindered by low participation. METHODS: A sample of non-responder women aged 35–64 years, belonging to three different programmes (in Rome, Florence and Teramo), was randomly split into...

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Autores principales: Giorgi Rossi, P, Marsili, L M, Camilloni, L, Iossa, A, Lattanzi, A, Sani, C, Di Pierro, C, Grazzini, G, Angeloni, C, Capparucci, P, Pellegrini, A, Schiboni, M L, Sperati, A, Confortini, M, Bellanova, C, D'Addetta, A, Mania, E, Visioli, C B, Sereno, E, Carozzi, F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031894/
https://www.ncbi.nlm.nih.gov/pubmed/21179038
http://dx.doi.org/10.1038/sj.bjc.6606040
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author Giorgi Rossi, P
Marsili, L M
Camilloni, L
Iossa, A
Lattanzi, A
Sani, C
Di Pierro, C
Grazzini, G
Angeloni, C
Capparucci, P
Pellegrini, A
Schiboni, M L
Sperati, A
Confortini, M
Bellanova, C
D'Addetta, A
Mania, E
Visioli, C B
Sereno, E
Carozzi, F
author_facet Giorgi Rossi, P
Marsili, L M
Camilloni, L
Iossa, A
Lattanzi, A
Sani, C
Di Pierro, C
Grazzini, G
Angeloni, C
Capparucci, P
Pellegrini, A
Schiboni, M L
Sperati, A
Confortini, M
Bellanova, C
D'Addetta, A
Mania, E
Visioli, C B
Sereno, E
Carozzi, F
author_sort Giorgi Rossi, P
collection PubMed
description BACKGROUND: In Italy, cervical cancer screening programmes actively invite women aged 25–64 years. Programmes are hindered by low participation. METHODS: A sample of non-responder women aged 35–64 years, belonging to three different programmes (in Rome, Florence and Teramo), was randomly split into four arms: two control groups received standard recall letters to perform either Pap-test (first group) or human papillomavirus (HPV) test (second group) at the clinic. A third arm was sent letters offering a self-sampler for HPV testing, to be requested by phone, whereas a fourth group was directly sent the self-samplers home. RESULTS: Compliance with standard recall was 13.9% (N619). Offering HPV test at the clinic had a nonsignificant effect on compliance (N616, relative risk (RR)=1.08; 95% CI=0.82–1.41). Self-sampler at request had the poorest performance, 8.7% (N622, RR=0.62; 95% CI=0.45–0.86), whereas direct mailing of the self-sampler registered the highest compliance: 19.6% (N616, RR=1.41; 95% CI=1.10–1.82). This effect on compliance was observed only in urban areas, Florence and Rome (N438, RR=1.69; 95% CI=1.24–2.30), but not in Abruzzo (N178, RR=0.95; 95% CI=0.61–1.50), a prevalently rural area. CONCLUSIONS: Mailing self-samplers to non-responders may increase compliance as compared with delivering standard recall letters. Nevertheless, effectiveness is context specific and the strategy costs should be carefully considered.
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spelling pubmed-30318942012-01-18 The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600) Giorgi Rossi, P Marsili, L M Camilloni, L Iossa, A Lattanzi, A Sani, C Di Pierro, C Grazzini, G Angeloni, C Capparucci, P Pellegrini, A Schiboni, M L Sperati, A Confortini, M Bellanova, C D'Addetta, A Mania, E Visioli, C B Sereno, E Carozzi, F Br J Cancer Clinical Study BACKGROUND: In Italy, cervical cancer screening programmes actively invite women aged 25–64 years. Programmes are hindered by low participation. METHODS: A sample of non-responder women aged 35–64 years, belonging to three different programmes (in Rome, Florence and Teramo), was randomly split into four arms: two control groups received standard recall letters to perform either Pap-test (first group) or human papillomavirus (HPV) test (second group) at the clinic. A third arm was sent letters offering a self-sampler for HPV testing, to be requested by phone, whereas a fourth group was directly sent the self-samplers home. RESULTS: Compliance with standard recall was 13.9% (N619). Offering HPV test at the clinic had a nonsignificant effect on compliance (N616, relative risk (RR)=1.08; 95% CI=0.82–1.41). Self-sampler at request had the poorest performance, 8.7% (N622, RR=0.62; 95% CI=0.45–0.86), whereas direct mailing of the self-sampler registered the highest compliance: 19.6% (N616, RR=1.41; 95% CI=1.10–1.82). This effect on compliance was observed only in urban areas, Florence and Rome (N438, RR=1.69; 95% CI=1.24–2.30), but not in Abruzzo (N178, RR=0.95; 95% CI=0.61–1.50), a prevalently rural area. CONCLUSIONS: Mailing self-samplers to non-responders may increase compliance as compared with delivering standard recall letters. Nevertheless, effectiveness is context specific and the strategy costs should be carefully considered. Nature Publishing Group 2011-01-18 2010-12-21 /pmc/articles/PMC3031894/ /pubmed/21179038 http://dx.doi.org/10.1038/sj.bjc.6606040 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Clinical Study
Giorgi Rossi, P
Marsili, L M
Camilloni, L
Iossa, A
Lattanzi, A
Sani, C
Di Pierro, C
Grazzini, G
Angeloni, C
Capparucci, P
Pellegrini, A
Schiboni, M L
Sperati, A
Confortini, M
Bellanova, C
D'Addetta, A
Mania, E
Visioli, C B
Sereno, E
Carozzi, F
The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600)
title The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600)
title_full The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600)
title_fullStr The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600)
title_full_unstemmed The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600)
title_short The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600)
title_sort effect of self-sampled hpv testing on participation to cervical cancer screening in italy: a randomised controlled trial (isrctn96071600)
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031894/
https://www.ncbi.nlm.nih.gov/pubmed/21179038
http://dx.doi.org/10.1038/sj.bjc.6606040
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