Cargando…
The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600)
BACKGROUND: In Italy, cervical cancer screening programmes actively invite women aged 25–64 years. Programmes are hindered by low participation. METHODS: A sample of non-responder women aged 35–64 years, belonging to three different programmes (in Rome, Florence and Teramo), was randomly split into...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031894/ https://www.ncbi.nlm.nih.gov/pubmed/21179038 http://dx.doi.org/10.1038/sj.bjc.6606040 |
_version_ | 1782197401477447680 |
---|---|
author | Giorgi Rossi, P Marsili, L M Camilloni, L Iossa, A Lattanzi, A Sani, C Di Pierro, C Grazzini, G Angeloni, C Capparucci, P Pellegrini, A Schiboni, M L Sperati, A Confortini, M Bellanova, C D'Addetta, A Mania, E Visioli, C B Sereno, E Carozzi, F |
author_facet | Giorgi Rossi, P Marsili, L M Camilloni, L Iossa, A Lattanzi, A Sani, C Di Pierro, C Grazzini, G Angeloni, C Capparucci, P Pellegrini, A Schiboni, M L Sperati, A Confortini, M Bellanova, C D'Addetta, A Mania, E Visioli, C B Sereno, E Carozzi, F |
author_sort | Giorgi Rossi, P |
collection | PubMed |
description | BACKGROUND: In Italy, cervical cancer screening programmes actively invite women aged 25–64 years. Programmes are hindered by low participation. METHODS: A sample of non-responder women aged 35–64 years, belonging to three different programmes (in Rome, Florence and Teramo), was randomly split into four arms: two control groups received standard recall letters to perform either Pap-test (first group) or human papillomavirus (HPV) test (second group) at the clinic. A third arm was sent letters offering a self-sampler for HPV testing, to be requested by phone, whereas a fourth group was directly sent the self-samplers home. RESULTS: Compliance with standard recall was 13.9% (N619). Offering HPV test at the clinic had a nonsignificant effect on compliance (N616, relative risk (RR)=1.08; 95% CI=0.82–1.41). Self-sampler at request had the poorest performance, 8.7% (N622, RR=0.62; 95% CI=0.45–0.86), whereas direct mailing of the self-sampler registered the highest compliance: 19.6% (N616, RR=1.41; 95% CI=1.10–1.82). This effect on compliance was observed only in urban areas, Florence and Rome (N438, RR=1.69; 95% CI=1.24–2.30), but not in Abruzzo (N178, RR=0.95; 95% CI=0.61–1.50), a prevalently rural area. CONCLUSIONS: Mailing self-samplers to non-responders may increase compliance as compared with delivering standard recall letters. Nevertheless, effectiveness is context specific and the strategy costs should be carefully considered. |
format | Text |
id | pubmed-3031894 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-30318942012-01-18 The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600) Giorgi Rossi, P Marsili, L M Camilloni, L Iossa, A Lattanzi, A Sani, C Di Pierro, C Grazzini, G Angeloni, C Capparucci, P Pellegrini, A Schiboni, M L Sperati, A Confortini, M Bellanova, C D'Addetta, A Mania, E Visioli, C B Sereno, E Carozzi, F Br J Cancer Clinical Study BACKGROUND: In Italy, cervical cancer screening programmes actively invite women aged 25–64 years. Programmes are hindered by low participation. METHODS: A sample of non-responder women aged 35–64 years, belonging to three different programmes (in Rome, Florence and Teramo), was randomly split into four arms: two control groups received standard recall letters to perform either Pap-test (first group) or human papillomavirus (HPV) test (second group) at the clinic. A third arm was sent letters offering a self-sampler for HPV testing, to be requested by phone, whereas a fourth group was directly sent the self-samplers home. RESULTS: Compliance with standard recall was 13.9% (N619). Offering HPV test at the clinic had a nonsignificant effect on compliance (N616, relative risk (RR)=1.08; 95% CI=0.82–1.41). Self-sampler at request had the poorest performance, 8.7% (N622, RR=0.62; 95% CI=0.45–0.86), whereas direct mailing of the self-sampler registered the highest compliance: 19.6% (N616, RR=1.41; 95% CI=1.10–1.82). This effect on compliance was observed only in urban areas, Florence and Rome (N438, RR=1.69; 95% CI=1.24–2.30), but not in Abruzzo (N178, RR=0.95; 95% CI=0.61–1.50), a prevalently rural area. CONCLUSIONS: Mailing self-samplers to non-responders may increase compliance as compared with delivering standard recall letters. Nevertheless, effectiveness is context specific and the strategy costs should be carefully considered. Nature Publishing Group 2011-01-18 2010-12-21 /pmc/articles/PMC3031894/ /pubmed/21179038 http://dx.doi.org/10.1038/sj.bjc.6606040 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Clinical Study Giorgi Rossi, P Marsili, L M Camilloni, L Iossa, A Lattanzi, A Sani, C Di Pierro, C Grazzini, G Angeloni, C Capparucci, P Pellegrini, A Schiboni, M L Sperati, A Confortini, M Bellanova, C D'Addetta, A Mania, E Visioli, C B Sereno, E Carozzi, F The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600) |
title | The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600) |
title_full | The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600) |
title_fullStr | The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600) |
title_full_unstemmed | The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600) |
title_short | The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600) |
title_sort | effect of self-sampled hpv testing on participation to cervical cancer screening in italy: a randomised controlled trial (isrctn96071600) |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031894/ https://www.ncbi.nlm.nih.gov/pubmed/21179038 http://dx.doi.org/10.1038/sj.bjc.6606040 |
work_keys_str_mv | AT giorgirossip theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT marsililm theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT camillonil theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT iossaa theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT lattanzia theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT sanic theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT dipierroc theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT grazzinig theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT angelonic theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT capparuccip theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT pellegrinia theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT schiboniml theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT speratia theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT confortinim theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT bellanovac theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT daddettaa theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT maniae theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT visiolicb theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT serenoe theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT carozzif theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT theeffectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT giorgirossip effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT marsililm effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT camillonil effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT iossaa effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT lattanzia effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT sanic effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT dipierroc effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT grazzinig effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT angelonic effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT capparuccip effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT pellegrinia effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT schiboniml effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT speratia effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT confortinim effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT bellanovac effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT daddettaa effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT maniae effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT visiolicb effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT serenoe effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT carozzif effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 AT effectofselfsampledhpvtestingonparticipationtocervicalcancerscreeninginitalyarandomisedcontrolledtrialisrctn96071600 |