LPS ligand and culture additives improve production of monomeric MD-1 and 2 in Pichia pastoris by decreasing aggregation and intermolecular disulfide bonding

Myeloid differentiation proteins MD-1 and MD-2 have both been shown to form a heterogeneous collection of oligomers when expressed in absence of their respective receptor, RP105 and TLR4. The biological relevance of these oligomers is not clear. Only monomeric proteins have been found to be active a...

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Detalles Bibliográficos
Autores principales: Mengwasser, Kristen E., Bryant, Clare E., Gay, Nick J., Gangloff, Monique
Formato: Texto
Lenguaje:English
Publicado: Academic Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032050/
https://www.ncbi.nlm.nih.gov/pubmed/21130168
http://dx.doi.org/10.1016/j.pep.2010.11.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032050/
https://www.ncbi.nlm.nih.gov/pubmed/21130168
http://dx.doi.org/10.1016/j.pep.2010.11.018

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