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Activation of sulfonate ester based matrix metalloproteinase proinhibitors by hydrogen peroxide
This study details the development of matrix metalloproteinase inhibitor prodrugs (proMMPi) that are activated in the presence of reactive-oxygen species (ROS). Conventional matrix metalloproteinase inhibitors (MMPi) utilize a zinc-binding group (ZBG) that chelates to the catalytic zinc(II) ion of m...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Springer-Verlag
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032223/ https://www.ncbi.nlm.nih.gov/pubmed/21049301 http://dx.doi.org/10.1007/s00775-010-0727-x |