Activation of sulfonate ester based matrix metalloproteinase proinhibitors by hydrogen peroxide

This study details the development of matrix metalloproteinase inhibitor prodrugs (proMMPi) that are activated in the presence of reactive-oxygen species (ROS). Conventional matrix metalloproteinase inhibitors (MMPi) utilize a zinc-binding group (ZBG) that chelates to the catalytic zinc(II) ion of m...

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Detalles Bibliográficos
Autores principales: Daniel, Kevin B., Major Jourden, Jody L., Negoescu, Kimberly E., Cohen, Seth M.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032223/
https://www.ncbi.nlm.nih.gov/pubmed/21049301
http://dx.doi.org/10.1007/s00775-010-0727-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032223/
https://www.ncbi.nlm.nih.gov/pubmed/21049301
http://dx.doi.org/10.1007/s00775-010-0727-x

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