Bcl-2-regulated cell death signalling in the prevention of autoimmunity

Cell death mediated through the intrinsic, Bcl-2-regulated mitochondrial apoptosis signalling pathway is critical for lymphocyte development and the establishment of central and maintenance of peripheral tolerance. Defects in Bcl-2-regulated cell death signalling have been reported to cause or corre...

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Detalles Bibliográficos
Autores principales: Tischner, D, Woess, C, Ottina, E, Villunger, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032315/
https://www.ncbi.nlm.nih.gov/pubmed/21364654
http://dx.doi.org/10.1038/cddis.2010.27
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author Tischner, D
Woess, C
Ottina, E
Villunger, A
author_facet Tischner, D
Woess, C
Ottina, E
Villunger, A
author_sort Tischner, D
collection PubMed
description Cell death mediated through the intrinsic, Bcl-2-regulated mitochondrial apoptosis signalling pathway is critical for lymphocyte development and the establishment of central and maintenance of peripheral tolerance. Defects in Bcl-2-regulated cell death signalling have been reported to cause or correlate with autoimmunity in mice and men. This review focuses on the role of Bcl-2 family proteins implicated in the development of autoimmune disorders and their potential as targets for therapeutic intervention.
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spelling pubmed-30323152011-02-24 Bcl-2-regulated cell death signalling in the prevention of autoimmunity Tischner, D Woess, C Ottina, E Villunger, A Cell Death Dis Review Cell death mediated through the intrinsic, Bcl-2-regulated mitochondrial apoptosis signalling pathway is critical for lymphocyte development and the establishment of central and maintenance of peripheral tolerance. Defects in Bcl-2-regulated cell death signalling have been reported to cause or correlate with autoimmunity in mice and men. This review focuses on the role of Bcl-2 family proteins implicated in the development of autoimmune disorders and their potential as targets for therapeutic intervention. Nature Publishing Group 2010-06 2010-06-03 /pmc/articles/PMC3032315/ /pubmed/21364654 http://dx.doi.org/10.1038/cddis.2010.27 Text en Copyright © 2010 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Review
Tischner, D
Woess, C
Ottina, E
Villunger, A
Bcl-2-regulated cell death signalling in the prevention of autoimmunity
title Bcl-2-regulated cell death signalling in the prevention of autoimmunity
title_full Bcl-2-regulated cell death signalling in the prevention of autoimmunity
title_fullStr Bcl-2-regulated cell death signalling in the prevention of autoimmunity
title_full_unstemmed Bcl-2-regulated cell death signalling in the prevention of autoimmunity
title_short Bcl-2-regulated cell death signalling in the prevention of autoimmunity
title_sort bcl-2-regulated cell death signalling in the prevention of autoimmunity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032315/
https://www.ncbi.nlm.nih.gov/pubmed/21364654
http://dx.doi.org/10.1038/cddis.2010.27
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