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CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity

Aminoglycoside-induced nephrotoxicity and ototoxicity is a major clinical problem. To understand how aminoglycosides, including gentamicin, induce cytotoxicity in the kidney proximal tubule and the inner ear, we identified gentamicin-binding proteins (GBPs) from mouse kidney cells by pulling down GB...

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Detalles Bibliográficos
Autores principales: Karasawa, T, Wang, Q, David, L L, Steyger, P S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032319/
https://www.ncbi.nlm.nih.gov/pubmed/21368867
http://dx.doi.org/10.1038/cddis.2010.80