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Functional phosphoproteomic analysis reveals cold-shock domain protein A to be a Bcr-Abl effector-regulating proliferation and transformation in chronic myeloid leukemia

One proposed strategy to suppress the proliferation of imatinib-resistant cells in chronic myeloid leukemia (CML) is to inhibit key proteins downstream of Bcr-Abl. The PI3K/Akt pathway is activated by Bcr-Abl and is specifically required for the growth of CML cells. To identify targets of this pathw...

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Detalles Bibliográficos
Autores principales: Sears, D, Luong, P, Yuan, M, Nteliopoulos, G, Man, Y K S, Melo, J V, Basu, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032323/
https://www.ncbi.nlm.nih.gov/pubmed/21368869
http://dx.doi.org/10.1038/cddis.2010.72