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Cytotoxicity of amyloidogenic immunoglobulin light chains in cell culture

Light-chain amyloidosis (AL) is a devastating protein-misfolding disease characterized by abnormal proliferation of plasma cells in the bone marrow that secrete monoclonal immunoglobulin light chains that misfold and form amyloid fibrils, thus causing organ failure and death. Numerous reports on dif...

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Detalles Bibliográficos
Autores principales: Sikkink, L A, Ramirez-Alvarado, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032327/
https://www.ncbi.nlm.nih.gov/pubmed/21368874
http://dx.doi.org/10.1038/cddis.2010.75