Phosphorylation of Puma modulates its apoptotic function by regulating protein stability

Puma is a potent BH3-only protein that antagonises anti-apoptotic Bcl-2 proteins, promotes Bax/Bak activation and has an essential role in multiple apoptotic models. Puma expression is normally kept very low, but can be induced by several transcription factors including p53, p73, E2F1 and FOXO3a, wh...

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Detalles Bibliográficos
Autores principales: Fricker, M, O'Prey, J, Tolkovsky, A M, Ryan, K M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032554/
https://www.ncbi.nlm.nih.gov/pubmed/21364664
http://dx.doi.org/10.1038/cddis.2010.38

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032554/
https://www.ncbi.nlm.nih.gov/pubmed/21364664
http://dx.doi.org/10.1038/cddis.2010.38

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