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Selenium toxicity but not deficient or super-nutritional selenium status vastly alters the transcriptome in rodents

BACKGROUND: Protein and mRNA levels for several selenoproteins, such as glutathione peroxidase-1 (Gpx1), are down-regulated dramatically by selenium (Se) deficiency. These levels in rats increase sigmoidally with increasing dietary Se and reach defined plateaus at the Se requirement, making them sen...

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Detalles Bibliográficos
Autores principales: Raines, Anna M, Sunde, Roger A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032699/
https://www.ncbi.nlm.nih.gov/pubmed/21226930
http://dx.doi.org/10.1186/1471-2164-12-26