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Characterization of thiobarbituric acid derivatives as inhibitors of hepatitis C virus NS5B polymerase

In an effort to find chemicals inhibiting the enzymatic activity of the hepatitis C virus (HCV) NS5B polymerase, a series of thiobarbituric acid derivatives were selected from a library provided by Korea Research Institute of Chemical Technology and characterized. The selected compounds exhibited IC...

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Detalles Bibliográficos
Autores principales: Lee, Jong-Ho, Lee, Sangyoon, Park, Mi Young, Myung, Heejoon
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032711/
https://www.ncbi.nlm.nih.gov/pubmed/21235805
http://dx.doi.org/10.1186/1743-422X-8-18