A PXR-Mediated Negative Feedback Loop Attenuates the Expression of CYP3A in Response to the PXR Agonist Pregnenalone-16α-Carbonitrile

The nuclear receptor superfamily of ligand-activated transcription factors plays a central role in the regulation of cellular responses to chemical challenge. Nuclear receptors are activated by a wide range of both endogenous and exogenous chemicals, and their target genes include those involved in...

Descripción completa

Detalles Bibliográficos
Autores principales: Bailey, Ian, Gibson, G. Gordon, Plant, Kathryn, Graham, Mark, Plant, Nick
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032768/
https://www.ncbi.nlm.nih.gov/pubmed/21311750
http://dx.doi.org/10.1371/journal.pone.0016703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032768/
https://www.ncbi.nlm.nih.gov/pubmed/21311750
http://dx.doi.org/10.1371/journal.pone.0016703

Ejemplares similares