Real time detection of peptide–MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability

The majority of known major histocompatibility complex class I (MHCI)-associated tumor-derived peptide antigens do not contain an optimal motif for MHCI binding. As a result, anchor residue-modified ‘heteroclitic’ peptides have been widely used in therapeutic cancer vaccination trials in order to en...

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Detalles Bibliográficos
Autores principales: Miles, Kim M., Miles, John J., Madura, Florian, Sewell, Andrew K., Cole, David K.
Formato: Texto
Lenguaje:English
Publicado: Pergamon Press 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032881/
https://www.ncbi.nlm.nih.gov/pubmed/21130497
http://dx.doi.org/10.1016/j.molimm.2010.11.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032881/
https://www.ncbi.nlm.nih.gov/pubmed/21130497
http://dx.doi.org/10.1016/j.molimm.2010.11.004

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