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Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease
BACKGROUND: Complement proteins and activation products have been found associated with neuropathology in Alzheimer's disease (AD). Recently, a C5a receptor antagonist was shown to suppress neuropathology in two murine models of AD, Tg2576 and 3xTg. Previously, a genetic deficiency of C1q in th...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033336/ https://www.ncbi.nlm.nih.gov/pubmed/21235806 http://dx.doi.org/10.1186/1742-2094-8-4 |