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In Situ Photodegradation of Incorporated Polyanion Does Not Alter Prion Infectivity

Single-stranded polyanions ≥40 bases in length facilitate the formation of hamster scrapie prions in vitro, and polyanions co-localize with PrP(Sc) aggregates in vivo [1], [2]. To test the hypothesis that intact polyanionic molecules might serve as a structural backbone essential for maintaining the...

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Detalles Bibliográficos
Autores principales: Piro, Justin R., Harris, Brent T., Supattapone, Surachai
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033378/
https://www.ncbi.nlm.nih.gov/pubmed/21304885
http://dx.doi.org/10.1371/journal.ppat.1002001