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In Situ Photodegradation of Incorporated Polyanion Does Not Alter Prion Infectivity
Single-stranded polyanions ≥40 bases in length facilitate the formation of hamster scrapie prions in vitro, and polyanions co-localize with PrP(Sc) aggregates in vivo [1], [2]. To test the hypothesis that intact polyanionic molecules might serve as a structural backbone essential for maintaining the...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033378/ https://www.ncbi.nlm.nih.gov/pubmed/21304885 http://dx.doi.org/10.1371/journal.ppat.1002001 |