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Selective Pressure to Increase Charge in Immunodominant Epitopes of the H3 Hemagglutinin Influenza Protein

The evolutionary speed and the consequent immune escape of H3N2 influenza A virus make it an interesting evolutionary system. Charged amino acid residues are often significant contributors to the free energy of binding for protein–protein interactions, including antibody–antigen binding and ligand–r...

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Detalles Bibliográficos
Autores principales: Pan, Keyao, Long, Jinxue, Sun, Haoxin, Tobin, Gregory J., Nara, Peter L., Deem, Michael W.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033527/
https://www.ncbi.nlm.nih.gov/pubmed/21086120
http://dx.doi.org/10.1007/s00239-010-9405-4