Multiple shRNA combinations for near-complete coverage of all HIV-1 strains

BACKGROUND: Combinatorial RNA interference (co-RNAi) approaches are needed to account for viral variability in treating HIV-1 with RNAi, as single short hairpin RNAs (shRNA) are rapidly rendered ineffective by resistant strains. Current work suggests that 4 simultaneously expressed shRNAs may preven...

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Detalles Bibliográficos
Autores principales: Mcintyre, Glen J, Groneman, Jennifer L, Yu, Yi-Hsin, Tran, Anna, Applegate, Tanya L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033792/
https://www.ncbi.nlm.nih.gov/pubmed/21226969
http://dx.doi.org/10.1186/1742-6405-8-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033792/
https://www.ncbi.nlm.nih.gov/pubmed/21226969
http://dx.doi.org/10.1186/1742-6405-8-1

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