2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP(+)-Dependent Isocitrate Dehydrogenase Mutations

BACKGROUND: Gliomas frequently contain mutations in the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase (IDH1) or the mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2). Several different amino acid substitutions recur at either IDH1 R132 or IDH2 R172 in glioma patients. Genetic...

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Detalles Bibliográficos
Autores principales: Jin, Genglin, Reitman, Zachary J., Spasojevic, Ivan, Batinic-Haberle, Ines, Yang, Jian, Schmidt-Kittler, Oleg, Bigner, Darell D., Yan, Hai
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033901/
https://www.ncbi.nlm.nih.gov/pubmed/21326614
http://dx.doi.org/10.1371/journal.pone.0016812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033901/
https://www.ncbi.nlm.nih.gov/pubmed/21326614
http://dx.doi.org/10.1371/journal.pone.0016812

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