Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure

AIMS/HYPOTHESIS: Carbohydrate-free diet prevents hyperglycaemia and beta cell destruction in the New Zealand Obese (NZO) mouse model. Here we have used a sequential dietary regimen to dissociate the effects of obesity and hyperglycaemia on beta cell function and integrity, and to study glucose-induc...

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Detalles Bibliográficos
Autores principales: Kluth, O., Mirhashemi, F., Scherneck, S., Kaiser, D., Kluge, R., Neschen, S., Joost, H.-G., Schürmann, A.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034032/
https://www.ncbi.nlm.nih.gov/pubmed/21107520
http://dx.doi.org/10.1007/s00125-010-1973-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034032/
https://www.ncbi.nlm.nih.gov/pubmed/21107520
http://dx.doi.org/10.1007/s00125-010-1973-8

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