Cargando…

Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure

AIMS/HYPOTHESIS: Carbohydrate-free diet prevents hyperglycaemia and beta cell destruction in the New Zealand Obese (NZO) mouse model. Here we have used a sequential dietary regimen to dissociate the effects of obesity and hyperglycaemia on beta cell function and integrity, and to study glucose-induc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kluth, O., Mirhashemi, F., Scherneck, S., Kaiser, D., Kluge, R., Neschen, S., Joost, H.-G., Schürmann, A.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034032/ https://www.ncbi.nlm.nih.gov/pubmed/21107520 http://dx.doi.org/10.1007/s00125-010-1973-8

Ejemplares similares

Role of Forkhead Box Protein O1 (FoxO1) in Stroke: A Literature Review
por: Guo, Sichao, et al.
Publicado: (2022)

Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics
por: Tabnak, Peyman, et al.
Publicado: (2023)

Prognostic implications of forkhead box protein O1 (FOXO1) and paired box 3 (PAX3) in epithelial ovarian cancer
por: Han, Gwan Hee, et al.
Publicado: (2019)

Hypericin maintians PDX1 expression via the Erk pathway and protects islet β-cells against glucotoxicity and lipotoxicity
por: Liang, Chen, et al.
Publicado: (2019)

Forkhead box O-class 1 and Forkhead box G1 as Prognostic Markers for Bladder Cancer
por: Kim, Tae-Hwan, et al.
Publicado: (2009)

Forkhead box protein O1 (FoxO1) /SERPINB1 ameliorates ROS production in diabetic nephropathy
por: Liang, Xiaoya, et al.
Publicado: (2020)

Metabolism and memory: α-synuclein level in children with obesity and children with type 1 diabetes; relation to glucotoxicity, lipotoxicity and executive functions
por: Salah, Nouran Yousef, et al.
Publicado: (2022)

Cross-Talking Pathways of Forkhead Box O1 (FOXO1) Are Involved in the Pathogenesis of Alzheimer's Disease and Huntington's Disease
por: Liu, Liyang, et al.
Publicado: (2022)

Research progress on the forkhead box C1
por: Wang, Jinhua, et al.
Publicado: (2017)

Alteration of Forkhead Box O (Foxo4) Acetylation Mediates Apoptosis of Podocytes in Diabetes Mellitus
por: Chuang, Peter Y., et al.
Publicado: (2011)

Squamosamide Derivative FLZ Protects Pancreatic β-Cells from Glucotoxicity by Stimulating Akt-FOXO1 Pathway
por: Kong, Xiangchen, et al.
Publicado: (2015)

Differential Control of iNKT Cell Effector Lineage Differentiation by the Forkhead Box Protein O1 (Foxo1) Transcription Factor
por: Tao, Huishan, et al.
Publicado: (2019)

Effect of Sleeve Gastrectomy on Glycometabolism via Forkhead Box O1 (FoxO1)/Lipocalin-2 (LCN2) Pathway
por: Liu, Zhi, et al.
Publicado: (2020)

Forkhead Box S1 Inhibits the Progression of Hepatocellular Carcinoma
por: Lei, Dengliang, et al.
Publicado: (2020)

The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity
por: Newman, Joseph A., et al.
Publicado: (2020)

Forkhead box K2 modulates epirubicin and paclitaxel sensitivity through FOXO3a in breast cancer
por: de Moraes, G Nestal, et al.
Publicado: (2015)

Forkhead box O (FOXO) 3 modulates hypoxia-induced autophagy through AMPK signalling pathway in cardiomyocytes
por: Chi, Yunpeng, et al.
Publicado: (2016)

Associations between Forkhead Box O1 (FoxO1) Expression and Indicators of Hepatic Glucose Production in Transition Dairy Cows Supplemented with Dietary Nicotinic Acid
por: Kinoshita, Asako, et al.
Publicado: (2016)

Uteroplacental insufficiency decreases forkhead box protein O1A (foxO1a) hepatic levels in perinatal and postnatal IUGR rats
por: Shen, Z, et al.
Publicado: (2013)

Gegen Qinlian Decoction Ameliorates Hepatic Insulin Resistance by Silent Information Regulator1 (SIRT1)-Dependent Deacetylation of Forkhead Box O1 (FOXO1)
por: Sui, Miao, et al.
Publicado: (2019)

RASSF1A Suppresses Estrogen-Dependent Breast Cancer Cell Growth through Inhibition of the Yes-Associated Protein 1 (YAP1), Inhibition of the Forkhead Box Protein M1 (FOXM1), and Activation of Forkhead Box Transcription Factor 3A (FOXO3A)
por: Roßwag, Sven, et al.
Publicado: (2020)

Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis
por: Zou, Yiyu, et al.
Publicado: (2008)

Dysregulation of FOXO1 (Forkhead Box O1 Protein) Drives Calcification in Arterial Calcification due to Deficiency of CD73 and Is Present in Peripheral Artery Disease
por: Moorhead, William J., et al.
Publicado: (2020)

MiroRNA-31-3p Promotes the Invasion and Metastasis of Non-Small-Cell Lung Cancer Cells by Targeting Forkhead Box 1 (FOXO1)
por: Zeng, Xiaoyuan, et al.
Publicado: (2022)

Forkhead Transcription Factor FOXO1 Inhibits Angiogenesis in Gastric Cancer in Relation to SIRT1
por: Kim, Sue Youn, et al.
Publicado: (2016)

Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy
por: Kandula, Vidya, et al.
Publicado: (2016)

FOXO1 forkhead domain mutants in B-cell lymphoma lack transcriptional activity
por: Sablon, Ariane, et al.
Publicado: (2022)

Retracted: MiroRNA-31-3p Promotes the Invasion and Metastasis of Non-Small-Cell Lung Cancer Cells by Targeting Forkhead Box 1 (FOXO1)
por: Methods in Medicine, Computational and Mathematical
Publicado: (2023)

The Dominant Role of Forkhead Box Proteins in Cancer
por: Bach, Duc-Hiep, et al.
Publicado: (2018)

SAT-150 Forkhead Box Protein O1 (foxo1) Regulates Hepatic Serine Protease Inhibitor B1 (serpinb1) Expression In A Cell Non-autonomous Fashion
por: El Ouaamari, Abdelfattah, et al.
Publicado: (2019)

Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo
por: Ananda Sadagopan, Suresh Kumar, et al.
Publicado: (2015)

The Role of Forkhead Box Q1 Transcription Factor in Ovarian Epithelial Carcinomas
por: Gao, Min, et al.
Publicado: (2012)

Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation
por: Bin, Lianghua, et al.
Publicado: (2016)

Forkhead box protein P1, a key player in neuronal development?
por: Braccioli, Luca, et al.
Publicado: (2018)

Tetramethylpyrazine inhibits prostate cancer progression by downregulation of forkhead box M1
por: Zhou, Yi, et al.
Publicado: (2017)

Forkhead Box Q1 Is Critical to Angiogenesis and Macrophage Recruitment of Colorectal Cancer
por: Tang, Hui, et al.
Publicado: (2020)

Forkhead Box I1 in Breast Carcinoma as a Potent Prognostic Factor
por: Onodera, Yoshiaki, et al.
Publicado: (2021)

The Glucotoxicity Protecting Effect of Ezetimibe in Pancreatic Beta Cells via Inhibition of CD36
por: Yoon, Ji Sung, et al.
Publicado: (2016)

Lipid-Induced Adaptations of the Pancreatic Beta-Cell to Glucotoxic Conditions Sustain Insulin Secretion
por: Oberhauser, Lucie, et al.
Publicado: (2021)

Forkhead Box Protein O3 Transcription Factor Negatively Regulates Autophagy in Human Cancer Cells by Inhibiting Forkhead Box Protein O1 Expression and Cytosolic Accumulation
por: Zhu, Wan Long, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_6gub2jni28n6jo2cjkpal54u34