DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence

When the cell cycle is arrested, growth-promoting pathways such as mTOR (Target of Rapamycin) drive cellular senescence, characterized by cellular hyper-activation, hypertrophy and permanent loss of the proliferative potential. While arresting cell cycle, p53 (under certain conditions) can inhibit t...

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Detalles Bibliográficos
Autores principales: Leontieva, Olga V., Blagosklonny, Mikhail V.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034181/
https://www.ncbi.nlm.nih.gov/pubmed/21212465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034181/
https://www.ncbi.nlm.nih.gov/pubmed/21212465

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