Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells

Oxidativue stress was shown to promote the translocation of Ataxia-telangiectasia mutated (ATM) to cytoplasm and trigger the LKB1-AMPK-tuberin pathway leading to a down-regulation of mTOR and subsequently inducing the programmed cell death II (autophagy). Cisplatin was previously found to induce the...

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Detalles Bibliográficos
Autores principales: Huang, Yiping, Ratovitski, Edward A.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034184/
https://www.ncbi.nlm.nih.gov/pubmed/21191146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034184/
https://www.ncbi.nlm.nih.gov/pubmed/21191146

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