Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells

Long INterspersed Element-1 (LINE-1 or L1) retrotransposition continues to impact human genome evolution1,2. L1s can retrotranspose in the germline, during early development, and in select somatic cells3,4,5,6,7,8; however, the host response to L1 retrotransposition remains largely unexplored. Here,...

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Detalles Bibliográficos
Autores principales: Garcia-Perez, Jose L., Morell, Maria, Scheys, Joshua O., Kulpa, Deanna A., Morell, Santiago, Carter, Christoph C., Hammer, Gary D., Collins, Kathleen L., O’Shea, K. Sue, Menendez, Pablo, Moran, John V.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034402/
https://www.ncbi.nlm.nih.gov/pubmed/20686575
http://dx.doi.org/10.1038/nature09209

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