A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged high-throughput biophysical screening

BACKGROUND: A newly identified mechanism of smooth muscle relaxation is the interaction between the small heat shock protein 20 (HSP20) and 14-3-3 proteins. Focusing upon this class of interactions, we describe here a novel drug target screening approach for treating airflow obstruction in asthma. M...

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Detalles Bibliográficos
Autores principales: An, Steven S, Askovich, Peter S, Zarembinski, Thomas I, Ahn, Kwangmi, Peltier, John M, von Rechenberg, Moritz, Sahasrabudhe, Sudhir, Fredberg, Jeffrey J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034681/
https://www.ncbi.nlm.nih.gov/pubmed/21232113
http://dx.doi.org/10.1186/1465-9921-12-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034681/
https://www.ncbi.nlm.nih.gov/pubmed/21232113
http://dx.doi.org/10.1186/1465-9921-12-8

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