Deletion of the thrombin cleavage domain of osteopontin mediates breast cancer cell adhesion, proteolytic activity, tumorgenicity, and metastasis

BACKGROUND: Osteopontin (OPN) is a secreted phosphoprotein often overexpressed at high levels in the blood and primary tumors of breast cancer patients. OPN contains two integrin-binding sites and a thrombin cleavage domain located in close proximity to each other. METHODS: To study the role of the...

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Detalles Bibliográficos
Autores principales: Beausoleil, Michel S, Schulze, Erika B, Goodale, David, Postenka, Carl O, Allan, Alison L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034707/
https://www.ncbi.nlm.nih.gov/pubmed/21247495
http://dx.doi.org/10.1186/1471-2407-11-25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034707/
https://www.ncbi.nlm.nih.gov/pubmed/21247495
http://dx.doi.org/10.1186/1471-2407-11-25

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