Cargando…

Deletion of the thrombin cleavage domain of osteopontin mediates breast cancer cell adhesion, proteolytic activity, tumorgenicity, and metastasis

BACKGROUND: Osteopontin (OPN) is a secreted phosphoprotein often overexpressed at high levels in the blood and primary tumors of breast cancer patients. OPN contains two integrin-binding sites and a thrombin cleavage domain located in close proximity to each other. METHODS: To study the role of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beausoleil, Michel S, Schulze, Erika B, Goodale, David, Postenka, Carl O, Allan, Alison L
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034707/ https://www.ncbi.nlm.nih.gov/pubmed/21247495 http://dx.doi.org/10.1186/1471-2407-11-25

Ejemplares similares

Thrombin Cleavage of Osteopontin and the Host Anti-Tumor Immune Response
por: Leung, Lawrence L., et al.
Publicado: (2023)

Inhibition of Cellular Adhesion by Immunological Targeting of Osteopontin Neoepitopes Generated through Matrix Metalloproteinase and Thrombin Cleavage
por: Jürets, Alexander, et al.
Publicado: (2016)

MBRS-22. SIGNIFICANCE OF RNF213 IN TUMORGENICITY OF MEDULLOBLASTOMA
por: Mineharu, Yohei, et al.
Publicado: (2020)

Thrombin cleavage of osteopontin controls activation of hepatic stellate cells and is essential for liver fibrogenesis
por: Cui, Guangying, et al.
Publicado: (2018)

EMT-independent detection of circulating tumor cells in human blood samples and pre-clinical mouse models of metastasis
por: Kitz, Jenna, et al.
Publicado: (2021)

Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo
por: Boggio, Elena, et al.
Publicado: (2016)

Correct proteolytic cleavage is required for the cell adhesive function of uvomorulin
Publicado: (1990)

Deletion of the Thrombin Proteolytic Site in Neurofascin 155 Causes Disruption of Nodal and Paranodal Organization
por: Dutta, Dipankar J., et al.
Publicado: (2021)

Proteolytic α-Synuclein Cleavage in Health and Disease
por: Bluhm, Alexandra, et al.
Publicado: (2021)

Biglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cells
por: Subbarayan, Karthikeyan, et al.
Publicado: (2022)

Targeting Asparagine Synthetase in Tumorgenicity Using Patient-Derived Tumor-Initiating Cells
por: Nishikawa, Gen, et al.
Publicado: (2022)

Epithelial-to-mesenchymal transition leads to disease-stage differences in circulating tumor cell detection and metastasis in pre-clinical models of prostate cancer
por: Lowes, Lori E., et al.
Publicado: (2016)

Proteolytic Cleavage of the Extracellular Domain Affects Signaling of Parathyroid Hormone 1 Receptor
por: Klenk, Christoph, et al.
Publicado: (2022)

Proteolytic Cleavage of Receptor Tyrosine Kinases
por: Huang, Hao
Publicado: (2021)

The Extended Cleavage Specificity of Human Thrombin
por: Gallwitz, Maike, et al.
Publicado: (2012)

Proteolytic cleavages in the extracellular domain of receptor tyrosine kinases by membrane-associated serine proteases
por: Chen, Li-Mei, et al.
Publicado: (2017)

Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration
por: Bieri, Gregor, et al.
Publicado: (2018)

Functional Diversity of Neuronal Cell Adhesion and Recognition Molecule L1CAM through Proteolytic Cleavage
por: Stoyanova, Irina I., et al.
Publicado: (2022)

Osteopontin Fragments with Intact Thrombin-Sensitive Site Circulate in Cervical Cancer Patients
por: Leung, Danny T. M., et al.
Publicado: (2016)

Syndecan‐4 Protects the Heart From the Profibrotic Effects of Thrombin‐Cleaved Osteopontin
por: Herum, Kate M., et al.
Publicado: (2020)

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor
Publicado: (1992)

Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain
por: Day, Ryan J., et al.
Publicado: (2016)

Fungal gasdermin-like proteins are controlled by proteolytic cleavage
por: Clavé, Corinne, et al.
Publicado: (2022)

The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin
por: Chahal, Gurdeep, et al.
Publicado: (2015)

Triple-Negative Primary Breast Tumors Induce Supportive Premetastatic Changes in the Extracellular Matrix and Soluble Components of the Lung Microenvironment
por: Medeiros, Braeden, et al.
Publicado: (2020)

Resistance to ursodeoxycholic acid-induced growth arrest can also result in resistance to deoxycholic acid-induced apoptosis and increased tumorgenicity
por: Powell, Ashley A, et al.
Publicado: (2006)

Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus
por: Yan, Xiaoxiang, et al.
Publicado: (2010)

Proteolytic cleavage of p53 mutants in response to mismatched DNA
por: Mee, T, et al.
Publicado: (1999)

Requirements for Efficient Proteolytic Cleavage of Prelamin A by ZMPSTE24
por: Barrowman, Jemima, et al.
Publicado: (2012)

Cleavage of HMGB1 by Proteolytic Enzymes Associated with Inflammatory Conditions
por: Sowinska, Agnieszka, et al.
Publicado: (2020)

Proteolytic cleavage of transmembrane cell adhesion molecule L1 by extracellular matrix molecule Reelin is important for mouse brain development
por: Lutz, David, et al.
Publicado: (2017)

Proteolytic signatures define unique thrombin-derived peptides present in human wound fluid in vivo
por: Saravanan, Rathi, et al.
Publicado: (2017)

Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage
por: Griparic, Lorena, et al.
Publicado: (2007)

STUDIES ON FERMENT ACTION : V. IMMUNIZATION WITH PROTEOLYTIC CLEAVAGE PRODUCTS OF PNEUMOCOCCI.
por: Jobling, James W., et al.
Publicado: (1912)

A pathway sensor for genome-wide screens of intracellular proteolytic cleavage
por: Ketteler, Robin, et al.
Publicado: (2008)

Proteolytic cleavage is required for functional neuroligin 2 maturation and trafficking in Drosophila
por: Tu, Renjun, et al.
Publicado: (2017)

Neutrophils and Activated Macrophages Control Mucosal Immunity by Proteolytic Cleavage of Antileukoproteinase
por: Vandooren, Jennifer, et al.
Publicado: (2018)

Microcin PDI regulation and proteolytic cleavage are unique among known microcins
por: Zhao, Zhe, et al.
Publicado: (2017)

Proteolytic chemokine cleavage as a regulator of lymphocytic infiltration in solid tumors
por: Bronger, Holger, et al.
Publicado: (2019)

Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage
por: Kumar, Senthil T., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ukm1slamjcceqlkptp3017edvv