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Autoantibodies to Endothelial Cell Surface ATP Synthase, the Endogenous Receptor for Hsp60, Might Play a Pathogenic Role in Vasculatides

BACKGROUND: Heat shock protein (hsp) 60 that provides “danger signal” binds to the surface of resting endothelial cells (EC) but its receptor has not yet been characterized. In mitochondria, hsp60 specifically associates with adenosine triphosphate (ATP) synthase. We therefore examined the possible...

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Detalles Bibliográficos
Autores principales: Alard, Jean-Eric, Hillion, Sophie, Guillevin, Loïc, Saraux, Alain, Pers, Jacques-Olivier, Youinou, Pierre, Jamin, Christophe
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034716/
https://www.ncbi.nlm.nih.gov/pubmed/21326874
http://dx.doi.org/10.1371/journal.pone.0014654