Effect of small interfering RNA 3'-end overhangs on chemosensitivity to thymidylate synthase inhibitors

BACKGROUND: Small interfering RNAs (siRNAs) are double-stranded RNAs that effectively inhibit expression of its complimentary target mRNA. Standard siRNAs contain two nucleotide overhangs on their 3' end. While these overhangs are usually comprised of deoxythymidines (dT), it has been shown tha...

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Detalles Bibliográficos
Autores principales: Schmitz, John C, Chu, Edward
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035029/
https://www.ncbi.nlm.nih.gov/pubmed/21247442
http://dx.doi.org/10.1186/1758-907X-2-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035029/
https://www.ncbi.nlm.nih.gov/pubmed/21247442
http://dx.doi.org/10.1186/1758-907X-2-1

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