Amplification of a plasmid bearing a mammalian replication initiation region in chromosomal and extrachromosomal contexts

Amplified genes in cancer cells reside on extrachromosomal double minutes (DMs) or chromosomal homogeneously staining regions (HSRs). We used a plasmid bearing a mammalian replication initiation region to model gene amplification. Recombination junctions in the amplified region were comprehensively...

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Detalles Bibliográficos
Autores principales: Harada, Seiyu, Sekiguchi, Naoki, Shimizu, Noriaki
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035466/
https://www.ncbi.nlm.nih.gov/pubmed/20929873
http://dx.doi.org/10.1093/nar/gkq882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035466/
https://www.ncbi.nlm.nih.gov/pubmed/20929873
http://dx.doi.org/10.1093/nar/gkq882

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