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Amplification of a plasmid bearing a mammalian replication initiation region in chromosomal and extrachromosomal contexts
Amplified genes in cancer cells reside on extrachromosomal double minutes (DMs) or chromosomal homogeneously staining regions (HSRs). We used a plasmid bearing a mammalian replication initiation region to model gene amplification. Recombination junctions in the amplified region were comprehensively...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035466/ https://www.ncbi.nlm.nih.gov/pubmed/20929873 http://dx.doi.org/10.1093/nar/gkq882 |