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The activity of the HIV-1 IRES is stimulated by oxidative stress and controlled by a negative regulatory element

Initiation of translation of the full-length messenger RNA of HIV-1, which generates the viral structural proteins and enzymes, is cap-dependent but can also use an internal ribosome entry site (IRES) located in the 5′ untranslated region. Our aim was to define, through a mutational analysis, region...

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Detalles Bibliográficos
Autores principales: Gendron, Karine, Ferbeyre, Gerardo, Heveker, Nikolaus, Brakier-Gingras, Léa
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035469/
https://www.ncbi.nlm.nih.gov/pubmed/20935056
http://dx.doi.org/10.1093/nar/gkq885