Fluoroquinolone Resistance Linked to GyrA, GyrB, and ParC Mutations in Salmonella enterica Typhimurium Isolates in Humans

We report two cases of infection with clonally unrelated, high-level ciprofloxacin-resistant, β-lactamase–producing strains of Salmonella enterica Typhimurium. Resistance was caused by four topoisomerase mutations, in GyrA, GyrB, and ParC and increased drug efflux. Ciprofloxacin treatment failed in...

Descripción completa

Detalles Bibliográficos
Autores principales: Casin, Isabelle, Breuil, Jacques, Darchis, Jean Pierre, Guelpa, Claire, Collatz, Ekkehard
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2003
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035553/
https://www.ncbi.nlm.nih.gov/pubmed/14718091
http://dx.doi.org/10.3201/eid0911.030317
_version_ 1782197784347148288
author Casin, Isabelle
Breuil, Jacques
Darchis, Jean Pierre
Guelpa, Claire
Collatz, Ekkehard
author_facet Casin, Isabelle
Breuil, Jacques
Darchis, Jean Pierre
Guelpa, Claire
Collatz, Ekkehard
author_sort Casin, Isabelle
collection PubMed
description We report two cases of infection with clonally unrelated, high-level ciprofloxacin-resistant, β-lactamase–producing strains of Salmonella enterica Typhimurium. Resistance was caused by four topoisomerase mutations, in GyrA, GyrB, and ParC and increased drug efflux. Ciprofloxacin treatment failed in one case. In the second case, reduced susceptibility to third-generation cephalosporins occurred after initial treatment with these drugs and may explain the treatment failure with ceftriaxone.
format Text
id pubmed-3035553
institution National Center for Biotechnology Information
language English
publishDate 2003
publisher Centers for Disease Control and Prevention
record_format MEDLINE/PubMed
spelling pubmed-30355532011-02-15 Fluoroquinolone Resistance Linked to GyrA, GyrB, and ParC Mutations in Salmonella enterica Typhimurium Isolates in Humans Casin, Isabelle Breuil, Jacques Darchis, Jean Pierre Guelpa, Claire Collatz, Ekkehard Emerg Infect Dis Dispatch We report two cases of infection with clonally unrelated, high-level ciprofloxacin-resistant, β-lactamase–producing strains of Salmonella enterica Typhimurium. Resistance was caused by four topoisomerase mutations, in GyrA, GyrB, and ParC and increased drug efflux. Ciprofloxacin treatment failed in one case. In the second case, reduced susceptibility to third-generation cephalosporins occurred after initial treatment with these drugs and may explain the treatment failure with ceftriaxone. Centers for Disease Control and Prevention 2003-11 /pmc/articles/PMC3035553/ /pubmed/14718091 http://dx.doi.org/10.3201/eid0911.030317 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Casin, Isabelle
Breuil, Jacques
Darchis, Jean Pierre
Guelpa, Claire
Collatz, Ekkehard
Fluoroquinolone Resistance Linked to GyrA, GyrB, and ParC Mutations in Salmonella enterica Typhimurium Isolates in Humans
title Fluoroquinolone Resistance Linked to GyrA, GyrB, and ParC Mutations in Salmonella enterica Typhimurium Isolates in Humans
title_full Fluoroquinolone Resistance Linked to GyrA, GyrB, and ParC Mutations in Salmonella enterica Typhimurium Isolates in Humans
title_fullStr Fluoroquinolone Resistance Linked to GyrA, GyrB, and ParC Mutations in Salmonella enterica Typhimurium Isolates in Humans
title_full_unstemmed Fluoroquinolone Resistance Linked to GyrA, GyrB, and ParC Mutations in Salmonella enterica Typhimurium Isolates in Humans
title_short Fluoroquinolone Resistance Linked to GyrA, GyrB, and ParC Mutations in Salmonella enterica Typhimurium Isolates in Humans
title_sort fluoroquinolone resistance linked to gyra, gyrb, and parc mutations in salmonella enterica typhimurium isolates in humans
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035553/
https://www.ncbi.nlm.nih.gov/pubmed/14718091
http://dx.doi.org/10.3201/eid0911.030317
work_keys_str_mv AT casinisabelle fluoroquinoloneresistancelinkedtogyragyrbandparcmutationsinsalmonellaentericatyphimuriumisolatesinhumans
AT breuiljacques fluoroquinoloneresistancelinkedtogyragyrbandparcmutationsinsalmonellaentericatyphimuriumisolatesinhumans
AT darchisjeanpierre fluoroquinoloneresistancelinkedtogyragyrbandparcmutationsinsalmonellaentericatyphimuriumisolatesinhumans
AT guelpaclaire fluoroquinoloneresistancelinkedtogyragyrbandparcmutationsinsalmonellaentericatyphimuriumisolatesinhumans
AT collatzekkehard fluoroquinoloneresistancelinkedtogyragyrbandparcmutationsinsalmonellaentericatyphimuriumisolatesinhumans

Ejemplares similares