Dissection of Splicing Regulation at an Endogenous Locus by Zinc-Finger Nuclease-Mediated Gene Editing

Sequences governing RNA splicing are difficult to study in situ due to the great difficulty of traditional targeted mutagenesis. Zinc-finger nuclease (ZFN) technology allows for the rapid and efficient introduction of site-specific mutations into mammalian chromosomes. Using a ZFN pair along with a...

Descripción completa

Detalles Bibliográficos
Autores principales: Cristea, Sandra, Gregory, Philip D., Urnov, Fyodor D., Cost, Gregory J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035666/
https://www.ncbi.nlm.nih.gov/pubmed/21347446
http://dx.doi.org/10.1371/journal.pone.0016961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035666/
https://www.ncbi.nlm.nih.gov/pubmed/21347446
http://dx.doi.org/10.1371/journal.pone.0016961

Ejemplares similares