2,4-Diaminopyrimidines as Potent Inhibitors of Trypanosoma brucei and Identification of Molecular Targets by a Chemical Proteomics Approach

BACKGROUND: There is an urgent need to develop new, safe and effective treatments for human African trypanosomiasis (HAT) because current drugs have extremely poor safety profiles and are difficult to administer. Here we report the discovery of 2,4-diaminopyrimidines, exemplified by 4-[4-amino-5-(2-...

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Detalles Bibliográficos
Autores principales: Mercer, Luke, Bowling, Tana, Perales, Joe, Freeman, Jennifer, Nguyen, Tien, Bacchi, Cyrus, Yarlett, Nigel, Don, Robert, Jacobs, Robert, Nare, Bakela
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035674/
https://www.ncbi.nlm.nih.gov/pubmed/21347454
http://dx.doi.org/10.1371/journal.pntd.0000956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035674/
https://www.ncbi.nlm.nih.gov/pubmed/21347454
http://dx.doi.org/10.1371/journal.pntd.0000956

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