Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus

The p53 tumor suppressor is a multifunctional protein, which regulates cell cycle, differentiation, DNA repair and apoptosis. Experimental seizures up-regulate p53 in the brain, and acute seizure-induced neuronal death can be reduced by genetic deletion or pharmacologic inhibition of p53. However, f...

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Detalles Bibliográficos
Autores principales: Engel, T, Tanaka, K, Jimenez-Mateos, E M, Caballero-Caballero, A, Prehn, J H M, Henshall, D C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035899/
https://www.ncbi.nlm.nih.gov/pubmed/21368852
http://dx.doi.org/10.1038/cddis.2010.55

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035899/
https://www.ncbi.nlm.nih.gov/pubmed/21368852
http://dx.doi.org/10.1038/cddis.2010.55

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