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Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus
The p53 tumor suppressor is a multifunctional protein, which regulates cell cycle, differentiation, DNA repair and apoptosis. Experimental seizures up-regulate p53 in the brain, and acute seizure-induced neuronal death can be reduced by genetic deletion or pharmacologic inhibition of p53. However, f...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035899/ https://www.ncbi.nlm.nih.gov/pubmed/21368852 http://dx.doi.org/10.1038/cddis.2010.55 |