Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells

Proton pump inhibitors (PPI) target tumour acidic pH and have an antineoplastic effect in melanoma. The PPI esomeprazole (ESOM) kills melanoma cells through a caspase-dependent pathway involving cytosolic acidification and alkalinization of tumour pH. In this paper, we further investigated the mecha...

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Detalles Bibliográficos
Autores principales: Marino, M L, Fais, S, Djavaheri-Mergny, M, Villa, A, Meschini, S, Lozupone, F, Venturi, G, Della Mina, P, Pattingre, S, Rivoltini, L, Codogno, P, De Milito, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035900/
https://www.ncbi.nlm.nih.gov/pubmed/21368860
http://dx.doi.org/10.1038/cddis.2010.67

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035900/
https://www.ncbi.nlm.nih.gov/pubmed/21368860
http://dx.doi.org/10.1038/cddis.2010.67

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