Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells

Chronic myeloid leukemia (CML) results from expression of the BCR/ABL oncogene in a primitive hematopoietic cell. However BCR/ABL-activated signaling mechanisms are dependent on the cellular context in which it is expressed, and mechanisms underlying primitive human hematopoietic cell transformation...

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Detalles Bibliográficos
Autores principales: Modi, Hardik, Li, Liang, Chu, Su, Rossi, John, Yee, Jiing-Kuan, Bhatia, Ravi
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036781/
https://www.ncbi.nlm.nih.gov/pubmed/21072043
http://dx.doi.org/10.1038/leu.2010.257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036781/
https://www.ncbi.nlm.nih.gov/pubmed/21072043
http://dx.doi.org/10.1038/leu.2010.257

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