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Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells
Chronic myeloid leukemia (CML) results from expression of the BCR/ABL oncogene in a primitive hematopoietic cell. However BCR/ABL-activated signaling mechanisms are dependent on the cellular context in which it is expressed, and mechanisms underlying primitive human hematopoietic cell transformation...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036781/ https://www.ncbi.nlm.nih.gov/pubmed/21072043 http://dx.doi.org/10.1038/leu.2010.257 |