An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody

The structural and functional significance of somatic insertions and deletions in antibody chains is unclear. Here, we demonstrate that a naturally occurring three-amino-acid insertion within the influenza virus-specific human monoclonal antibody 2D1 heavy-chain variable region reconfigures the anti...

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Detalles Bibliográficos
Autores principales: Krause, Jens C., Ekiert, Damian C., Tumpey, Terrence M., Smith, Patricia B., Wilson, Ian A., Crowe, James E.
Formato: Texto
Lenguaje:English
Publicado: American Society of Microbiology 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037006/
https://www.ncbi.nlm.nih.gov/pubmed/21304166
http://dx.doi.org/10.1128/mBio.00345-10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037006/
https://www.ncbi.nlm.nih.gov/pubmed/21304166
http://dx.doi.org/10.1128/mBio.00345-10

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